Fatigue and depression – what is our body trying to tell us?

The most important thing

• Fatigue and depression? When should we pay attention?

• Which medical conditions are associated with fatigue and depression?

• When should we seek professional help?

• Which symptoms indicate thyroid gland dysfunction?

• Steps that support thyroid health and the symptoms arising from its dysfunction.

Temporary episodes of fatigue and depression are somewhat to be expected in our busy, stressful everyday lives. This does not mean we should ignore them when we feel that way, especially if they persist for a prolonged period. Fatigue and depression can result from various factors. It is important to know what these factors might be so that we know how to proceed.

For these symptoms, we can support the body with Sarita+. This product is specifically designed to improve thyroid function in hypothyroidism. Its active ingredients support the production of thyroid hormones. This supports the body’s proper functioning.

Sources of depression and fatigue that we sometimes neglect

When we are overloaded with work and constant commitments, it is inevitable that we begin to experience mood changes. Sometimes we also experience chronic fatigue and depression. Sometimes this is a perfectly normal and expected condition that is temporary. Regardless, experts insist that we pay serious attention to these states, as they can have serious consequences for our health if they become chronic. 

What are the most common causes:

• Chronic stress. Chronic stress can have a serious impact on physical and mental health. When stress levels remain high for an extended period, the body can become overloaded, leading to fatigue and contributing to the development of depression.

• Medications. Some medications (antidepressants, antihistamines, beta-blockers, and opioids) have side effects such as fatigue and depression. If you suspect that your medication may be contributing to these symptoms, it is important to discuss your concerns with your doctor. Specialists can adjust the dosage or prescribe an alternative medication that is less likely to cause these side effects.

• Hormonal imbalance. Changes in hormone levels, such as those during menopause, pregnancy or a hormonal imbalance, can affect mood and energy levels. In men, reduced testosterone levels can cause feelings of depression and fatigue in everyday life.

• Dehydration. Water plays a key role in our health. It regulates body temperature and helps transport nutrients to our cells. Dehydration, especially in the warmer months, can cause fatigue, fuzzy thinking and mood swings. Good hydration is important all year round.

• Lack of sleep. Quality sleep is crucial for our health, and a lack of it can seriously affect our energy levels and mood. A lack of sleep does not directly lead to depression, but it increases the risk of it and can worsen it.

Which diseases can cause fatigue and depression?

Symptoms such as fatigue and depression are often the result of various illnesses. These conditions are very difficult for those who suffer from them [1]. We usually do not think to link fatigue and depression with any specific disease. However, it is important to be aware of which diseases can cause them, so that we know what to do for our health.

• Chronic diseases. Chronic conditions such as multiple sclerosis, fibromyalgia and rheumatoid arthritis can lead to serious sleep disturbances and cause daytime fatigue. This significantly increases the risk of developing depressive disorders [2].

• Mental disorders. Mental disorders such as bipolar disorder and schizophrenia can cause feelings of fatigue and changes in mood, thinking and behaviour.

•  Impaired thyroid gland function. Impaired thyroid gland function is another factor that can lead to fatigue and depression. This gland plays a key role in regulating metabolism through the production of thyroid hormones. Changes in its function lead to conditions of hypothyroidism and hyperthyroidism. In hypothyroidism, for example, thyroid function is reduced. This usually leads to fatigue, lethargy, difficulty concentrating and depressive states.

Symptoms of reduced thyroid function

The thyroid gland is involved in controlling many processes in the human body. This includes regulating metabolism and energy production, as well as the functioning of various organs. When it does not function properly, various symptoms may occur, such as fatigue, lethargy and difficulty concentrating, poor mood and weight gain. Sometimes depression can also be a symptom. 

Hypothyroidism can cause hair loss, weight gain, memory problems and dry skin. Symptoms such as cold extremities and constipation are also common. Irregular menstrual cycles in women and a feeling of constant nervousness are also common signs. Hypothyroidism is often accompanied by fatigue that cannot be explained by other causes. 

Recognising these symptoms enables early diagnosis and appropriate treatment. If the symptoms are persistent or severe, it is important to consult a doctor. The doctor will refer you for the necessary blood tests to determine your thyroid hormone levels and recommend appropriate treatment.

When is it important to seek medical help?

The fast pace of modern life often forces us to ignore the symptoms of fatigue and depression. We accept them as a normal part of our lives. We often fail to heed the signals our body sends us. It is important to remember that when these symptoms persist, it is essential to seek professional help.

Chronic stress, fatigue and depression can be controlled by various methods. They can be divided into two main groups: psychological and medical. Psychological approaches include therapies such as cognitive-behavioural therapy and psychosomatic methods, which are useful for conditions such as fatigue, depression and lethargy [4].

We should seek medical help when these symptoms are accompanied by certain physiological signs. Changes such as constipation, skin problems and weight issues are often associated with hypothyroidism. Blood tests are the quickest way to detect possible disorders in our body. In such cases, a treatment plan is drawn up with the help of a doctor. It usually includes medication and lifestyle changes.

What can we do to improve thyroid gland function?

The thyroid gland is important for the overall health of our body. It is the largest endocrine gland in the body and is responsible for a number of important functions. These include regulating metabolism, maintaining growth and development, and balancing energy levels. Its proper functioning requires special care and preventive measures. 

Experts advise us to stick to a healthy diet, engage in regular physical activity and take supplements. These steps are important for the proper functioning of the thyroid gland.

• Regular exercise. Cardio exercises such as walking, running or swimming are useful for managing the symptoms of reduced thyroid function, such as lack of energy and fatigue. Muscle-strengthening exercises are beneficial for speeding up the metabolism.

• Supplementation. It is often difficult to obtain all the essential micronutrients and vitamins we need from food alone. Not all fruits and vegetables are available year-round, and in our fast-paced daily lives, eating a varied diet can be a challenge. This can lead to deficiencies that have negative effects on our health. This is where supplementation comes in. 

The composition of Sarita+ helps to tackle the most common symptoms of hypothyroidism, such as fatigue and depression, and supports the body in overcoming these challenges. Its comprehensive formula offers all-round care for individuals with reduced function of this vital gland.

• Healthy diet. Trace minerals, such as selenium and zinc, are important for maintaining thyroid function. They are found in foods such as oysters, seafood, pulses and dairy products. Eating more fruit and vegetables is also important for thyroid health. Additionally, certain fruits and vegetables have a proven effect on the thyroid gland. Spinach is one example. It contains high concentrations of iodine and vitamins A and K. Research shows that consuming spinach can improve thyroid function and help maintain optimal levels of thyroid hormones. Broccoli is rich in folic acid and vitamin C, which are also important for thyroid health. 

An example of a fruit with a beneficial effect on the thyroid gland is the apricot. It is a source of vitamin A, which is important for its function. Apples are rich in fibre and vitamin C. Bromelain plays a role in maintaining a healthy thyroid gland. Pineapple is a rich source of this enzyme.

Many fermented foods are also beneficial for thyroid health. Foods such as yoghurt and fermented vegetables have a positive effect on the thyroid gland. In addition to the thyroid gland, they are also beneficial for gut flora health and a strong immune system [5].

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CHZV

Which deficiency can cause fatigue and depression?

• There are various causes of fatigue and depression, but one possible cause may be a deficiency of a particular micronutrient. One of the most common deficiencies associated with these symptoms is vitamin D deficiency. Its deficiency is linked to symptoms such as unexplained fatigue, feelings of sadness, poor sleep and muscle weakness.

Which thyroid hormones are important?

• The thyroid gland produces the hormones triiodothyronine (T3) and thyroxine (T4), which are involved in many functions in the body. Most commonly, blood tests for thyroid health include measuring T3 and T4 levels, as well as thyroid-stimulating hormone (TSH). TSH is not produced by the thyroid gland but by the pituitary gland, another gland located in the skull. TSH regulates the functions of the thyroid gland and is the most sensitive indicator for assessing thyroid function.

When should we seek help for symptoms of fatigue and depression?

• If the symptoms are purely psychological, then cognitive-behavioural and other psychological approaches can help. If the symptoms also include physiological changes, such as those associated with thyroid dysfunction, you should consult a doctor.

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Sources:

• https://www.medicalnewstoday.com/articles/322264#complications

• https://www.cedars-sinai.org/health-library/diseases-and-conditions/s/seasonal-affective-disorder-or-sad.html

•  https://www.ncbi.nlm.nih.gov/books/NBK500006/

• https://magazine.medlineplus.gov/article/hypothyroidism-vs-hyperthyroidism-whats-the-difference

References:

1. Malhi GS, Mann JJ. Depression. Lancet. 24 November 2018;392(10161):2299-2312. doi: 10.1016/S0140-6736(18)31948-2. Published online 2 November 2018. Major depression is a common disorder that severely impairs psychosocial functioning and reduces quality of life. In 2008, the WHO ranked major depression as the third leading cause of disease burden worldwide and predicted that the illness would rank first by 2030.1 In practice, its detection, diagnosis and treatment often present a challenge for clinicians due to its varied manifestations, unpredictable course and prognosis, as well as its variable response to treatment.

2. Chmielewski, G., Majewski, M. S., Kuna, J., Mikiewicz, M., & Krajewska-Włodarczyk, M. (2023). Fatigue in inflammatory joint diseases. International journal of molecular sciences, 24(15), 12040. https://doi.org/10.3390/ijms241512040me. Fatigue is a common symptom in various rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. It is characterised as a subjective, persistent feeling of general weariness or exhaustion, which affects the patient’s quality of life and exacerbates disability. The nature of fatigue is multifaceted, encompassing physiological, psychological, and social factors, and although the exact cause of inflammatory joint diseases is not fully understood, several factors are thought to contribute to its development. Despite its high prevalence and importance, this symptom is often underestimated in clinical practice.

3. Selim Shahjada, Mustari Marufa, Khan Taushik Ahmed, Kamrul-Hasan ABM. 2024. An approach to the management of hypothyroidism and hyperthyroidism in Bangladesh: a national survey from the physicians’ perspective, Frontiers in Endocrinology, 14; DOI=10.3389/fendo.2023.1322335. Among these disorders, hypothyroidism, whether subclinical or overt, is the most common, especially in women. Hypothyroidism initially manifests as an increase in serum TSH concentration along with normal serum concentrations of free T4 and triiodothyronine (T3) (subclinical hypothyroidism), followed by a decrease in serum free T4 concentration. On the other hand, the main biochemical abnormality in hyperthyroidism is initially a suppressed TSH concentration along with a normal serum concentration of total T4 (subclinical hyperthyroidism), followed by an increased serum concentration of total T4 (explicit hyperthyroidism).

4. Nakao, M., Shirotsuki, K., & Sugaya, N. (2021). Cognitive-behavioural therapy for managing mental health and stress-related disorders: Recent advances in techniques and technologies. BioPsychoSocial medicine, 15(1), 16. https://doi.org/10.1186/s13030-021-00219-ws. Cognitive Behavioural Therapy (CBT) helps individuals to eliminate avoidance behaviours and safety-seeking behaviours that prevent the self-correction of faulty beliefs, thereby facilitating stress management to reduce stress-related disorders and improve mental health. This review assessed the efficacy of CBT under stressful conditions in clinical and general populations and identified recent advances in CBT-related techniques.

5. Babiker, A., Alavi, A., Al Atawi, M. and Al Alwan, I. (2020). The role of micronutrients in thyroid dysfunction. Sudanese Journal of Paediatrics, 20(1), 13–19. https://doi.org/10.24911/SJP.106-1587138942. Thyroid hormones are essential for normal growth and development in children. Nutrition is closely linked to thyroid gland dysfunction due to a deviation from the gland’s normal physiology. Iodine, the main component of thyroid hormones (T3 and T4), is deficient in, and its deficiency is one of the most common causes of hypothyroidism in children and adults worldwide. Other micronutrients, such as vegetables from the Brassicaceae family (cross-family vegetables), pearl millet, soya products, and cassava, are also associated with causing thyroid dysfunction. Environmental factors, namely the contamination of water with goitrogens, can also contribute to the aetiology of goitre in some endemic areas. Nutritional recommendations and avoiding excessive dietary goitrogen intake are part of the food safety guidelines that should be established, particularly in endemic areas.